کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5908844 | 1570170 | 2015 | 5 صفحه PDF | دانلود رایگان |
- The reported rs7574865 (STAT4) and rs9275319 (HLA-DQ) were not replicated with HCC.
- The rs7574865 and rs9275319 were significantly associated with the risk of CHB.
- The decreased mRNA expression of STAT4, HLA-DQ genes in HCC tissue was observed.
- Our results might provide a clue to understanding of the progression to HCC.
A recent genome-wide association study (GWAS) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) identified two loci (rs7574865 in STAT4 and rs9275319 in HLA-DQ) in a Chinese population. We attempted to replicate the associations between the two SNP loci and the risk of HCC in a Korean population. The rs7574865 in STAT4 and rs9275319 in HLA-DQ were genotyped in a total of 3838 Korean subjects composed of 287 HBV-related hepatocellular carcinoma patients, 671 chronic hepatitis B virus (CHB) patients, and 2880 population controls using TaqMan genotyping assay. Gene expression was measured by microarray. A logistic regression analysis revealed that rs7574865 in STAT4 and rs9275319 in HLA-DQ were associated with the risk of CHB (ORÂ =Â 1.25, PÂ =Â 0.0002 and ORÂ =Â 1.57, PÂ =Â 1.44Â ÃÂ 10â10, respectively). However, these loci were no association with the risk of HBV-related HCC among CHB patients. In the gene expression analyses, although no significant differences in mRNA expression of nearby genes according to genotypes were detected, a significantly decreased mRNA expression in HCC subjects was observed in STAT4, HLA-DQA1, and HLA-DQB1. Although the genetic effects of two HCC susceptibility loci were not replicated, the two loci were found to exert susceptibility effects on the risk of CHB in a Korean population. In addition, the decreased mRNA expression of STAT4, HLA-DQA1, and HLA-DQB1 in HCC tissue might provide a clue to understanding their role in the progression to HCC.
Journal: Infection, Genetics and Evolution - Volume 33, July 2015, Pages 72-76