کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5911123 | 1570185 | 2013 | 9 صفحه PDF | دانلود رایگان |
- NoV was identified in the stools of diarrheal patients and controls in HCMC.
- The locations of the NoV infections were GPS mapped.
- A novel NoV GII.4-2010 (New Orleans) variant was detected.
- The NoV GII.4-2010 demonstrated a significant spatiotemporal signal.
Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood. The spatiotemporal distribution of NoV genotypes identified in 2054 enrolled children was investigated between May 2009 and December 2010, in Ho Chi Minh City (HCMC), Vietnam. A total of 315 NoV extracted from stool samples were genotyped and GPS mapped to their source. Genogroup II NoV, particularly GII.4, were predominant, and the GII.4 strains could be subgrouped into GII.4-2006b (Minerva) and GII.4-2010 (New Orleans) variants. There was no spatiotemporal structure among the endemic GII strains; yet a significant spatiotemporal signal corresponding with the novel introduction of GII.4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010.
Journal: Infection, Genetics and Evolution - Volume 18, August 2013, Pages 335-343