کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5912157 | 1570210 | 2016 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis](/preview/png/5912157.png)
- HLA-DRB*1501 influences the risk of developing multiple sclerosis but it is not known how it affects grey matter pathology.
- Lesional and normal-appearing cortical grey matter magnetization transfer ratio were measured in MS and healthy controls.
- No significant differences were observed in MRI measures between the HLA-DRB*1501 subgroups.
BackgroundThe HLA-DRB*1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology.AimTo assess HLA-DRB*1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology.MethodsWhole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB*1501 haplotype was determined by genotyping (rs3135388).ResultsNo significant differences were observed in MRI measures between the HLA-DRB*1501 subgroups.ConclusionsThe HLA-DRB*1501 haplotype is not strongly associated with MRI-visible grey matter pathology.
Journal: Multiple Sclerosis and Related Disorders - Volume 7, May 2016, Pages 47-52