کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5937607 | 1573448 | 2009 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nano-Scaled Particles of Titanium Dioxide Convert Benign Mouse Fibrosarcoma Cells into Aggressive Tumor Cells
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Nanoparticles are prevalent in both commercial and medicinal products; however, the contribution of nanomaterials to carcinogenesis remains unclear. We therefore examined the effects of nano-sized titanium dioxide (TiO2) on poorly tumorigenic and nonmetastatic QR-32 fibrosarcoma cells. We found that mice that were cotransplanted subcutaneously with QR-32 cells and nano-sized TiO2, either uncoated (TiO2â1, hydrophilic) or coated with stearic acid (TiO2â2, hydrophobic), did not form tumors. However, QR-32 cells became tumorigenic after injection into sites previously implanted with TiO2â1, but not TiO2â2, and these developing tumors acquired metastatic phenotypes. No differences were observed either histologically or in inflammatory cytokine mRNA expression between TiO2â1 and TiO2â2 treatments. However, TiO2â2, but not TiO2â1, generated high levels of reactive oxygen species (ROS) in cell-free conditions. Although both TiO2â1 and TiO2â2 resulted in intracellular ROS formation, TiO2â2 elicited a stronger response, resulting in cytotoxicity to the QR-32 cells. Moreover, TiO2â2, but not TiO2â1, led to the development of nuclear interstices and multinucleate cells. Cells that survived the TiO2 toxicity acquired a tumorigenic phenotype. TiO2-induced ROS formation and its related cell injury were inhibited by the addition of antioxidant N-acetyl-l-cysteine. These results indicate that nano-sized TiO2 has the potential to convert benign tumor cells into malignant ones through the generation of ROS in the target cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Pathology - Volume 175, Issue 5, November 2009, Pages 2171-2183
Journal: The American Journal of Pathology - Volume 175, Issue 5, November 2009, Pages 2171-2183
نویسندگان
Kunishige Onuma, Yu Sato, Satomi Ogawara, Nobuyuki Shirasawa, Masanobu Kobayashi, Jun Yoshitake, Tetsuhiko Yoshimura, Masaaki Iigo, Junichi Fujii, Futoshi Okada,