کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5954712 | 1173320 | 2014 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Arterial Stiffness in COPD
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کلمات کلیدی
PWVFMDAIXFSCMMP-9ICSRAASLong-acting β-agonist - آگونیست β-طولانی مدتtumor necrosis factor-α - تومور نکروز عامل αPulse wave velocity - سرعت موج پالسAge - سنLABA - سودRenin-angiotensin-aldosterone system - سیستم رنین-آنژیوتانسین-آلدوسترونAugmentation index - شاخص تقویتTNF-α - فاکتور نکروز توموری آلفاMatrix metalloproteinase 9 - ماتریکس متالوپروتئیناز 9Nitric oxide - نیتریک اکسیدFlow-mediated vasodilatation - واسط انعقاد ناشی از جریانC-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی advanced glycation end product - پیشرفته محصول نهایی گلیساسیونInhaled corticosteroid - کورتیکواستروئیدهای استنشاقی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In patients with COPD, cardiovascular diseases are the most common concomitant chronic diseases, a leading cause of hospitalization, and one of the main causes of death. A close connection exists between COPD and cardiovascular diseases. Cardiovascular risk scores aim to predict the effect of cardiovascular comorbidities on COPD mortality, but there is a need to better characterize occult and suboccult cardiovascular disease, even in patients with mild to moderate COPD. Among various surrogate markers of cardiovascular risk, arterial stiffness plays a central role and is a strong independent predictor of cardiovascular events beyond classic cardiovascular risk factors. Its measurement is highly suitable, validated, and relatively easy to perform in routine COPD clinical practice. The growing awareness of the increased cardiovascular risk associated with COPD has led to a call for respiratory physicians to measure arterial pulse wave velocity in routine practice. Cross-sectional data establish elevated arterial stiffness as being independently linked to COPD. Candidate mechanisms have been proposed, but surprisingly, only limited data are available regarding the impact of the different COPD treatment modalities on arterial stiffness, although initial studies have suggested a significant positive impact. In this review, we present the various surrogate markers of cardiovascular morbidity in COPD and the central role of arterial stiffness and the underlying mechanisms explaining vascular remodeling in COPD. We also consider the therapeutic impact of COPD medications and exercise training on arterial stiffness and the assessments that should be implemented in COPD care and follow-up.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chest - Volume 145, Issue 4, April 2014, Pages 861-875
Journal: Chest - Volume 145, Issue 4, April 2014, Pages 861-875
نویسندگان
Isabelle PhD, Renaud MD, PhD, Jean-Philippe MD, PhD, Jean Christian PhD, Patrick MD, PhD, Jean-Louis MD, PhD,