Post-seizure drug treatment in young rats determines clear incremental losses of frontal cortical and hippocampal neurons: The resultant damage is similar to very old brains

► Seizure-induced neuronal loss in young brains approximates very old age. ► Frontal cortices and hippocampal formations are most affected. ► Late-treated seizures result in neuronal density of very old brains. ► Post-seizure ketamine ameliorates the neuronal deficits.