A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats - implications for treating complex partial seizures

► Chronic fish oil supplementation to rats increased amygdaloid seizure threshold. ► This effect was mediated by docosahexaenoic (DHA) but not eicosapentaenoic acid. ► Fish oil containing DHA may be effective against human complex-partial seizures.