Effect of saponin fraction from Ficus religiosa on memory deficit, and behavioral and biochemical impairments in pentylenetetrazol kindled mice

► Saponin-rich fraction (SRF) of Ficus religiosa prevented seizures in kindled mice. ► SRF treatment showed protection against kindling-associated depression in mice. ► SRF treatment increased monoamine level in discrete brain regions of kindled mice. ► SRF treatment modulated amino acid level in discrete brain regions of kindled mice.