کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6015447 | 1186069 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Frontolimbic brain networks predict depressive symptoms in temporal lobe epilepsy
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کلمات کلیدی
PFCDTIAPFAFNIFOVFunctional connectivity - اتصال عملکردی Depression - افسردگیanalysis of functional neuroimages - تجزیه و تحلیل از عوارض عملکردیecho time - زمان اکوRepetition time - زمان تکرارtemporal lobe epilepsy - صرع لوب تمپورالUncinate fasciculus - فیشیکولوس را بریدگی کنیدprefrontal cortex - قشر prefrontalMedial temporal - متوسط زمانیField of view - میدان دیدSurface mapping - نقشه برداری سطحیComorbidity - همبودی، وجود همزمان دو بیماری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Psychiatric co-morbidities in epilepsy are of great concern. The current study investigated the relative contribution of structural and functional connectivity (FC) between medial temporal (MT) and prefrontal regions in predicting levels of depressive symptoms in patients with temporal lobe epilepsy (TLE). Twenty-one patients with TLE [11 left TLE (LTLE); 10 right TLE (RTLE)] and 20 controls participated. Diffusion tensor imaging was performed to obtain fractional anisotropy (FA) of the uncinate fasciculus (UF), and mean diffusivity (MD) of the amygdala (AM) and hippocampus (HC). Functional MRI was performed to obtain FC strengths between the AM and HC and prefrontal regions of interest including anterior prefrontal (APF), orbitofrontal, and inferior frontal regions. Participants self-reported depression symptoms on the Beck Depression Inventory-II. Greater depressive symptoms were associated with stronger FC of ipsilateral HC-APF, lower FA of the bilateral UF, and higher MD of the ipsilateral HC in LTLE, and with lower FA of the contralateral UF in RTLE. Regression analyses indicated that FC of the ipsilateral HC-APF was the strongest contributor to depression in LTLE, explaining 68.7% of the variance in depression scores. Both functional and microstructural measures of frontolimbic dysfunction were associated with depressive symptoms. These connectivity variables may be moderating which patients present with depression symptoms. In particular, FC MRI may provide a more sensitive measure of depression-related dysfunction, at least in patients with LTLE. Employing sensitive measures of frontolimbic network dysfunction in TLE may help provide new insight into mood disorders in epilepsy that could eventually guide treatment planning.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 108, Issue 9, November 2014, Pages 1554-1563
Journal: Epilepsy Research - Volume 108, Issue 9, November 2014, Pages 1554-1563
نویسندگان
Nobuko Kemmotsu, N. Erkut Kucukboyaci, Kelly M. Leyden, Christopher E. Cheng, Holly M. Girard, Vicente J. Iragui, Evelyn S. Tecoma, Carrie R. McDonald,