Cerebralcare Granule® attenuates blood-brain barrier disruption after middle cerebral artery occlusion in rats

► Brain edema due to BBB injury by I/R presses microvessels, reducing brain perfusion. ► Treatment with CG for 3 h of I/R, reduces brain edema, perfusion and infarction. ► CG reduces brain edema by interference in tight junction proteins and caveolin-1.