Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

► Beclin-1 is an important protein involved in autophagy. ► In Alzheimer's, the depletion of this protein may lead to neurodegeneration. ► We examined if Beclin-1 is cleaved by caspases in the Alzheimer's brain. ► Results indicate depletion of Beclin-1 in Alzheimer's due to cleavage by caspases.