کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6087427 | 1207364 | 2015 | 8 صفحه PDF | دانلود رایگان |
- Antibody production against GAA is delayed during anti-BAFF immunotherapy.
- Anti-BAFF protects against ERT-related anaphylaxis.
- Delayed antibody production is associated with increased GAA activity in tissues.
- Continued BAFF blockade prevents the formation and migration of GAA-specific plasmablasts into the bone marrow.
Antibodies formed against the therapeutic protein are a life-threatening complication that arises during enzyme replacement therapy for Pompe disease (acid α-glucosidase deficiency; GAA). To provide an effective alternative to current practices, we investigated the capacity of anti-B-cell activating factor (BAFF) as a novel drug candidate to prevent antibody formation in a Pompe disease mouse model. A BAFF-neutralizing antibody was administered prophylactically and with maintenance doses in association with enzyme replacement therapy using recombinant human GAA in Gaaâ/â mice. BAFF blockade delayed antibody production and increased GAA activity within tissues with protection from anaphylaxis. Anti-BAFF also resolved antibody formation during an immune response and precluded the maturation of antibody secreting cells from entering the bone marrow compartment. This treatment modality may therefore be a viable alternative for the clinical management of antibody formation for Pompe disease and has potential use against antibody formation in other protein replacement therapies.
Journal: Clinical Immunology - Volume 158, Issue 2, June 2015, Pages 140-147