کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6140466 | 1594251 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response
ترجمه فارسی عنوان
تکرار تولیدی کروناویروس سندرم تنفسی خاورمیانه در سلولهای دندریتیک مونوسیت ممانعت کننده پاسخ ایمنی ذاتی است
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
چکیده انگلیسی
The Middle East respiratory syndrome coronavirus (MERS-CoV) closely resembled severe acute respiratory syndrome coronavirus (SARS-CoV) in disease manifestation as rapidly progressive acute pneumonia with multi-organ dysfunction. Using monocyte-derived-dendritic cells (Mo-DCs), we discovered fundamental discrepancies in the outcome of MERSâCoVâ and SARS-CoV-infection. First, MERS-CoV productively infected Mo-DCs while SARS-CoV-infection was abortive. Second, MERS-CoV induced significantly higher levels of IFN-γ, IP-10, IL-12, and RANTES expression than SARS-CoV. Third, MERS-CoV-infection induced higher surface expression of MHC class II (HLA-DR) and the co-stimulatory molecule CD86 than SARS-CoV-infection. Overall, our data suggests that the dendritic cell can serve as an important target of viral replication and a vehicle for dissemination. MERS-CoV-infection in DCs results in the production of a rich combination of cytokines and chemokines, and modulates innate immune response differently from that of SARS-CoV-infection. Our findings may help to explain the apparent discrepancy in the pathogenicity between MERS-CoV and SARS-CoV.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volumes 454â455, April 2014, Pages 197-205
Journal: Virology - Volumes 454â455, April 2014, Pages 197-205
نویسندگان
Hin Chu, Jie Zhou, Bosco Ho-Yin Wong, Cun Li, Zhong-Shan Cheng, Xiang Lin, Vincent Kwok-Man Poon, Tianhao Sun, Candy Choi-Yi Lau, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Kwok-Hung Chan, Liwei Lu, Bo-Jian Zheng, Kwok-Yung Yuen,