کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6150683 1596429 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A randomized phase II dose-response exercise trial among colon cancer survivors: Purpose, study design, methods, and recruitment results
ترجمه فارسی عنوان
یک آزمایش فیزیکی دوز فازی فاز دوم تصادفی در میان بازماندگان سرطان کولون: هدف، طراحی مطالعه، روش ها و نتایج استخدام
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی

BackgroundObservational studies indicate that higher volumes of physical activity are associated with improved disease outcomes among colon cancer survivors. The aim of this report is to describe the purpose, study design, methods, and recruitment results of the courage trial, a National Cancer Institute (NCI) sponsored, phase II, randomized, dose-response exercise trial among colon cancer survivors.Methods/resultsThe primary objective of the courage trial is to quantify the feasibility, safety, and physiologic effects of low-dose (150 min·week−1) and high-dose (300 min·week−1) moderate-intensity aerobic exercise compared to usual-care control group over six months. The exercise groups are provided with in-home treadmills and heart rate monitors. Between January and July 2015, 1433 letters were mailed using a population-based state cancer registry; 126 colon cancer survivors inquired about participation, and 39 were randomized onto the study protocol. Age was associated with inquiry about study participation (P < 0.001) and randomization onto the study protocol (P < 0.001). No other demographic, clinical, or geographic characteristics were associated with study inquiry or randomization. The final trial participant was randomized in August 2015. Six month endpoint data collection was completed in February 2016.DiscussionThe recruitment of colon cancer survivors into an exercise trial is feasible. The findings from this trial will inform key design aspects for future phase 2 and phase 3 randomized controlled trials to examine the efficacy of exercise to improve clinical outcomes among colon cancer survivors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contemporary Clinical Trials - Volume 47, March 2016, Pages 366-375
نویسندگان
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