کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6182971 1254057 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The influence of age and other prognostic factors associated with survival of ovarian immature teratoma - A study of 1307 patients
ترجمه فارسی عنوان
تأثیر سن و سایر عوامل پیش آگهی مرتبط با بقاء تراتوم نابالغ تخمدان - مطالعه 1307 بیمار
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی


- The survival of patients with stage I disease was 99.7%.
- Children and adults had corresponding survivals of 100% and 99.6% in stage I disease.
- The proportion of Asian patients with immature teratomas is disproportionately high.

ObjectiveTo determine impact of age and other prognostic factors on the survival of ovarian immature teratoma (IT) patients.MethodsData obtained from the SEER database between 1973 and 2012. Kaplan-Meier methods and multivariate Cox regression models were used for statistical analyses.ResultsOf 1307 patients (median: 24 years; range: 0-93), 78%, 5%, 13%, 4% were stages I, II, III and IV, respectively. 25%, 35%, and 40% had grades 1, 2, and 3. Whites were less likely to be diagnosed, and Asians had a nearly 3-fold higher proportion of IT compared to the proportion of Asians in the U.S. census. The 5-year disease-specific survival (DSS) was 91.2%. Those with stages I, II, III and IV disease had survivals of 99.7%, 95%, 81%, and 71.8% (p < 0.001) and grades 1, 2, and 3 had DSS of 98.7%, 95.8%, and 91% (p < 0.001), respectively. Of those who underwent fertility-preserving surgery, the DSS was 98.8%. Over time from 1973 to 1986, to 1987-1999, to 2000-2012, the survivals were 76.4%, 92.8%, and 94.7% (p < 0.001). Of stage I patients, no patient < 18 years (n = 214, used as adult cutoff) and 2 of 283 patients > 18 years died of cancer, with corresponding 5 years DSS of 100% vs. 99.6% (p > 0.05). Older age (by year, HR: 1.05; 95% CI: 1.04-1.06; p < 0.0001) and higher stage (HR: 11.52; 95% CI: 4.08-32.48; p < 0.0001) were independent factors indicating poorer survival.ConclusionThe outcome of patients with stage I disease was excellent at 99.7%, with children and adults having corresponding survivals of 100% and 99.6%.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 142, Issue 3, September 2016, Pages 446-451
نویسندگان
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