A novel curcumin-based vaginal cream Vacurin selectively eliminates apposed human cervical cancer cells

► The study shows the selective efficacy of the spice component curcumin in eliminating HPV(+) human cervical cancer cells. ► It develops a curcumin-based vaginal cream, Vacurin-20, and demonstrates its efficacy in eliminating apposed cervical cancer cells. ► This preclinical study establishes Vacurin-20 as a safe medication in an in vivo mouse model.