کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6196414 1602579 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Topical trans-resveratrol ameliorates steroid-induced anterior and posterior segment changes in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی و میکروب شناسی (عمومی)
پیش نمایش صفحه اول مقاله
Topical trans-resveratrol ameliorates steroid-induced anterior and posterior segment changes in rats
چکیده انگلیسی


- Repeated dose topical application of trans-resveratrol 0.2% causes:
- Sustained intraocular pressure reduction in steroid-induced ocular hypertensive rats.
- Increased aqueous humor total MMP-2 level.
- Reduced trabecular meshwork (TM) thickness and increased TM cell count.
- Restoration of the thickness of ganglion cell layer and inner retina.
- Restoration of the retinal redox status.

Steroid-induced hypertension and glaucoma is associated with increased extracellular meshwork (ECM) deposition in trabecular meshwork (TM). Previous studies have shown that single drop application of trans-resveratrol lowers IOP in steroid-induced ocular hypertensive (SIOH) rats. This IOP lowering is attributed to activation of adenosine A1 receptors, which may lead to increased matrix metalloproteinase (MMP)-2 activity. This study evaluated the effect of repeated topical application of trans-resveratrol for 21 days in SIOH animals on IOP, changes in MMP-2 level in aqueous humor, trabecular meshwork and retinal morphology and retinal redox status. We observed that treatment with trans-resveratrol results in significant and sustained IOP reduction in SIOH rats. This IOP reduction is associated with significantly higher aqueous humor total MMP-2 level; significantly reduced TM thickness and increased number of TM cells. Treatment with trans-resveratrol also significantly increased ganglion cell layer (GCL) thickness, the linear cell density in the GCL and inner retina thickness; and significantly reduced retinal oxidative stress compared to the SIOH vehicle-treated group. In conclusion, repeated dose topical application of trans-resveratrol produces sustained IOP lowering effect, which is associated with increased level of aqueous humor MMP-2, normalization of TM and retinal morphology and restoration of retinal redox status.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 143, February 2016, Pages 9-16
نویسندگان
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