کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6203966 1603293 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Osteoarthritis biomarkers derived from cartilage extracellular matrix: Current status and future perspectives
ترجمه فارسی عنوان
بیومارکرهای استئوآرتریت مشتق از ماتریکس خارج سلولی غضروف: وضعیت فعلی و چشم انداز آینده
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
چکیده انگلیسی

Specific soluble biomarkers can be powerful tools for the diagnosis, prognosis and personalized management of osteoarthritis (OA). Biomarkers are potential indicators of the effect of a drug on cartilage metabolism and provide crucial information about the mechanisms of drug action. In this review, we address key questions concerning the use of biomarkers in OA management: Why do we need soluble biomarkers? What are the most widely investigated biomarkers derived from cartilage extracellular matrix? What are the most common pitfalls in interpreting soluble biomarker measurements? What are the perspectives and future research directions in this field? We review current evidence to propose that cartilage-derived soluble biomarkers are complementary “drug development tools” that can be applied during drug development from preclinical research to clinical evaluation. In the future, such biomarkers could be surrogate markers of clinical and/or imaging outcomes. Successful standardization and implementation of automated biomarker assays will facilitate their use in companion diagnostics in the context of personalized medicine for enhanced management of OA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Physical and Rehabilitation Medicine - Volume 59, Issue 3, June 2016, Pages 145-148
نویسندگان
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