کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6219744 | 1607435 | 2015 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A Patent Ductus Arteriosus Severity Score Predicts Chronic Lung Disease or Death before Discharge A Patent Ductus Arteriosus Severity Score Predicts Chronic Lung Disease or Death before Discharge](/preview/png/6219744.png)
ObjectivesTo test the hypothesis that a patent ductus arteriosus (PDA) severity score (PDAsc) incorporating markers of pulmonary overcirculation and left ventricular (LV) diastolic function can predict chronic lung disease or death before discharge (CLD/death).Study designA multicenter prospective observational study was conducted for infants <29Â weeks gestation. An echocardiogram was carried out on day 2 to measure PDA diameter and maximum flow velocity, LV output, diastolic flow in the descending aorta and celiac trunk, and variables of LV function using tissue Doppler imaging. Predictors of CLD/death were identified using logistic regression methods. A PDAsc was created and a receiver operating characteristic curve was constructed to assess its ability to predict CLD/death.ResultsWe studied 141 infants at a mean (SD) gestation and birthweight of 26 (1.4) weeks and 952 (235) g, respectively. Five variables were identified that were independently associated with CLD/death (gestation at birth, PDA diameter, maximum flow velocity, LV output, and LV aâ² wave). The PDAsc had a range from 0 (low risk) to 13 (high risk). Infants who developed CLD/death had a higher score than those who did not (7.3 [1.8] vs 3.8 [2.0], PÂ <Â .001). PDAsc had an area under the curve of 0.92 (95% CI 0.86-0.97, PÂ <Â .001) for the ability to predict CLD/death. A PDAsc cut-off of 5 has sensitivity and specificity of 92% and 87%, and positive and negative predictive values of 92% and 82%, respectively.ConclusionsA PDAsc on day 2 can predict the later occurrence of CLD/death further highlighting the association between PDA significance and morbidity.
Journal: The Journal of Pediatrics - Volume 167, Issue 6, December 2015, Pages 1354-1361.e2