کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6222757 | 1607464 | 2013 | 8 صفحه PDF | دانلود رایگان |
ObjectiveTo review the literature and test the hypothesis that the use of antipyretic drugs in children with acute infections slows recovery.Study designA systematic review and meta-analysis of the literature was undertaken to investigate the effect of antipyretic drugs upon recovery from infectious diseases in children. A search of Medline (1946 until November 2012) and EMBASE (1980 until November 1, 2012) was undertaken to identify studies in which the authors compared the use of antipyretic medications with nonpharmacologic treatments for fever.ResultsSix papers were identified, 5 of which were included in the meta-analysis. Three studies focused on children with malaria and the other 3 considered general viral and respiratory infections and varicella. The pooled mean difference in time to fever clearance was 4.16 hours and was faster in those receiving antipyretics compared with those not (95% CI â6.35 to â1.96 hours; P = .0002). There was little evidence of statistical heterogeneity (Ï2Â 4.84; 4 df; P = .3; I2 17%).ConclusionThere is no evidence from these studies that the use of antipyretics slows the resolution of fever in children.
Journal: The Journal of Pediatrics - Volume 163, Issue 3, September 2013, Pages 822-827.e2