کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6262396 1613796 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research reportCerebral and extracerebral vulnerability to hypoxic insults after diffuse traumatic brain injury in rats
ترجمه فارسی عنوان
گزارش تحقیق آسیب پذیری مغزی و خارجی مغزی به سوء مصرف مواد مخدر در موش های صحرایی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- In rats, HH after a diffuse TBI increases hypoxia injuries in the cerebral cortex.
- It tends to increase hypoxia injuries in the thalamus, hippocampus and striatum.
- No significant hypoxic consequences were reported for the heart and the liver.
- TBI by itself appears to induce renal hypoxia.

The post-traumatic brain vulnerability suggests that after traumatic brain injury (TBI), the brain may be more susceptible to posttraumatic hypoxic insults. This concept could be extended to 'peripheral' organs, as non-neurologic organ failure is common after TBI. This study aims to characterize and quantify cerebral and extracerebral tissue hypoxia with pimonidazole resulting from a standardized hypoxia-hypotension (HH) phase occurring after a diffuse experimental TBI in rats. Rats were allocated to Sham (n=5), TBI (n=7), HH (n=7) and TBI+HH (n=7) groups. Then, pimonidazole was injected and brain, liver, heart and kidneys were analysed. In the cerebral cortex, post-treatment hypoxia was higher in TBI+HH group than Sham group (p=0.003), HH group (p=0.003) and TBI group (p=0.002). Large trends in thalamus, hippocampus and striatum for the TBI+HH group compared to the other groups were observed. For the heart and liver, the 4 groups were comparable. For the kidneys, post-treatment hypoxia was higher in the TBI group compared to the Sham and HH groups, but not more than TBI+HH group. This study reveals that a posttraumatic hypoxic insult occurring after a severe TBI has major hypoxic consequences on brain structures. However, TBI by itself appears to induce renal hypoxia that is not enhanced by posttraumatic hypoxic insult.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1646, 1 September 2016, Pages 334-341
نویسندگان
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