کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6262961 1613817 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Allopurinol protects against ischemic insults in a mouse model of cortical microinfarction
ترجمه فارسی عنوان
آلوپورینول در برابر عفونت های ایسکمیک در یک مدل موس از میکروآنفارکت کورتیزول محافظت می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- A mouse model of cortical microinfarction induced by two-photon laser irradiation.
- Allopurinol confers protection in microinfarction.
- Allopurinol decreases the infarct volume, inhibit inflammation and nitrosative stress.

Microinfarcts are common in patients with cognitive decline and dementia. Allopurinol (ALLO), a xanthine oxidase (XO) enzyme inhibitor, has been found to reduce proinflammatory molecules and oxidative stress in the vasculature. We here examined the effect of pre-treatment with allopurinol on the cortical microinfarction. C57BL/6J mice were subjected to a permanent single penetrating arteriole occlusion induced by two-photon laser irradiation. Infarction volume, the activation of glial cells and nitrosative stress in the ischemic brain was assessed using immunohistochemistry. Pre-treatment with ALLO achieved 42% reduction of infarct volume and significantly reduced microglia infiltration, astrocyte proliferation and nitrosative stress in the ischemic brain. These data indicate that ALLO protects against microinfarcts possibly through inhibition of nitrosative stress and attenuation of microglia infiltration as well as astrocytes reactivation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1622, 5 October 2015, Pages 361-367
نویسندگان
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