Vitamin D deficiency leads to sensory and sympathetic denervation of the rat synovium

- Inflammatory arthritis is linked to vitamin D deficiency and synovial denervation.
- Intimal synovial nerves are sensory and most contain both CGRP & GFRα2.
- Vitamin D deficiency reduces intimal density of neurturin (GFRα2 ligand)-ir cells.
- Vitamin D deficiency reduces the intimal density of sensory nerves.
- Vitamin D deficiency reduces subintimal density of sympathetic (TH-ir) nerves.