Getting ahead of oneself: Anticipation and the vestibulo-ocular reflex

► The changes of central cholinergic circuits were examined in post-stroke dementia mice. ► Anticipatory eye movements replace the vestibulo-ocular reflex (VOR) during voluntary head turns. ► Icariin can restore the damage of histone acetylation in cholinergic circuits. ► A model that simulates VOR and anticipatory responses and is applicable either to guinea pigs or primates is described.