کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6276793 | 1295744 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Basal dendrites are present in newly born dentate granule cells of young but not aged pilocarpine-treated chronic epileptic rats
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
DGCYSEMWMTLEDcxSRSphosphate buffer - بافر فسفاتstatus epilepticus - بحران صرعی یا صرع پایدارEpilepsy - بیماری صرعspontaneous recurrent seizures - تشنج مجدد خودبخودیBasal dendrites - دندریت های پایه ایdoublecortin - دوچرخهgranule cells - سلول های گرانولDentate granule cells - سلول های گرانول دندانیdentate gyrus - شکنج دندانه دارtemporal lobe epilepsy - صرع لوب تمپورالMorris water maze - ماز آب آب موریسHippocampus - هیپوکامپ Pilocarpine - پیلوکارپین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Epilepsy is known to influence hippocampal dentate granule cell (DGC) layer neurogenesis. In young adult rats, status epilepticus (SE) increases the number DGC newly borne cells and basal dendrites (BD), which persist at long-term. In contrast, little is known on whether these phenomena occur in elderly epileptic animals. In the present study, we compare DGC proliferation and the incidence of BD in young and aged pilocarpine-treated rats. Three epileptic groups were considered: Young animals given pilocarpine at 3 months of age. Aged animals treated with pilocarpine at 3 months of age that were sacrificed at 17-20 months. Aged animals that had pilocarpine and developed SE at 20 months, being sacrificed 2 months later. Nine days prior to sacrifice, animals underwent swimming sessions in the Morris water maze as a protocol for the development of hippocampal neurogenesis. We found a higher incidence of newly born DGC cells in young as compared to aged epileptic animals (P<0.001). This later group however, was not homogeneous. While a significant increase in DGC neurogenesis was observed when aged animals with long lasting epilepsy were compared to non-epileptic controls (P<0.01), this has not been recorded in aged animals that had epilepsy for only 2 months (P>0.05). When the number of DGC containing BD was considered, a significantly higher incidence was observed in young as compared to aged epileptic rats (P=0.001). Animals in this later group virtually lacked BD in newly formed dentate gyrus (DG) cells. Based on these results we conclude that plastic changes during epileptogenesis and the development of a pathological substrate in young animals is associated with DGC proliferation and the emergence of BD. As aging occurs, DGC neurogenesis can still be induced in rats with a long-term history of epilepsy but the emergence of BD is markedly reduced.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 170, Issue 3, 27 October 2010, Pages 687-691
Journal: Neuroscience - Volume 170, Issue 3, 27 October 2010, Pages 687-691
نویسندگان
R.D.T. Avanzi, C.F. Cavarsan, J.G. Jr, C. Hamani, L.E. Mello, L. Covolan,