کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278095 | 1295793 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Voltage-dependent calcium signaling in rat cerebellar unipolar brush cells
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کلمات کلیدی
TrpHEPESUBCROILJPAMPA4-APNMDAN-methyl-d-aspartateVGLUTmGluR4-aminopyridine - 4-آمینوپیریدینN-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid - N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acidTetraethyl ammonium - tetraethyl ammoniumLow threshold - آستانه کمvesicular glutamate transporter - حمل و نقل گلوتامات vesicularUnipolar brush cell - سلول برس یونیپلارCerebellum - مخچهRegions Of Interest - مناطق مورد علاقهLiquid junction potential - پتانسیل اتصال مایعtransient receptor potential - پتانسیل گیرنده گذراTEA - چایL-type calcium channels - کانال های کلسیم L نوعT-type calcium channels - کانال های کلسیم T نوعCalcium - کلسیمGABA - گاباMetabotropic glutamate receptor - گیرنده گلوتامات متابوتروپیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Unipolar brush cells (UBCs) are a class of excitatory interneuron found in the granule cell layer of the vestibulocerebellum. Mossy fibers form excitatory inputs on to the paint brush shaped dendrioles in the form of giant, glutamatergic synapses, activation of which results in prolonged bursts of action potentials in the postsynaptic UBC. The axons of UBCs themselves form mossy fiber contacts with other UBCs and granule cells, forming an excitatory, intrinsic cerebellar network that has the capacity to synchronize and amplify mossy fiber inputs to potentially large populations of granule cells. In this paper, we demonstrate that UBCs in rat cerebellar slices express low voltage activated (LVA) fast-inactivating and high voltage activated (HVA) slowly inactivating calcium channels. LVA calcium currents are mediated by T-type calcium channels and they are associated with calcium increases in the dendrites and to a lesser extent the cell soma. HVA currents, mediated by L-type calcium channels, are slowly inactivating and they produce larger overall increases in intracellular calcium but with a similar distribution pattern. We review these observations alongside several recent papers that examine how intrinsic membrane properties influence UBCs firing patterns and we discuss how UBC signaling may affect downstream cerebellar processing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 162, Issue 3, 1 September 2009, Pages 702-712
Journal: Neuroscience - Volume 162, Issue 3, 1 September 2009, Pages 702-712
نویسندگان
S. Birnstiel, N.T. Slater, D.R. McCrimmon, E. Mugnaini, N.A. Hartell,