کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6282577 | 1615142 | 2013 | 6 صفحه PDF | دانلود رایگان |
- Several peptides are expressed in the PVN-RVLM neurons.
- The large majority of PVN-RVLM neurons expressed OT and Dyn.
- The PVN-RVLM neurons predominantly co-expressed multiple peptides.
- Peptides were differentially distributed between subdivisions of PVN-RVLM neurons.
The hypothalamic paraventricular nucleus (PVN) exerts a major regulatory role in the endocrine and the autonomic system. It has anatomically and functionally distinct cell populations, one of which projects to the rostral ventrolateral medulla (PVN-RVLM) and are involved in the sympathetic regulation of the cardiovascular system. To investigate the expression and the distributional patterns of peptides in the PVN-RVLM neurons of rats, we used single cell RT-PCR analysis in combination with retrograde tracing. Approximately 80% of PVN-RVLM neurons expressed oxytocin (OT) and 60% expressed dynorphin (Dyn). There were differential distributions of peptides between the subdivisions of PVN-RVLM neurons. The posterior parvocellular subdivision predominantly expressed OT; the dorsal cap subdivision contained much less vasopressin (VP) compared to other subdivisions. In addition, PVN-RVLM neurons preponderantly co-expressed multiple peptides. These results suggest that peptides may contribute to elaborate responses of PVN to various stimuli.
Journal: Neuroscience Letters - Volume 556, 27 November 2013, Pages 160-165