کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6283361 1615154 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
BIN1 gene rs744373 polymorphism contributes to Alzheimer's disease in East Asian population
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
BIN1 gene rs744373 polymorphism contributes to Alzheimer's disease in East Asian population
چکیده انگلیسی
Large-scale genome-wide association studies (GWAS) identified BIN1 gene rs744373 polymorphism to be significantly associated with Alzheimer's disease (AD) in Caucasian ancestry. Recently, this polymorphism was also investigated in East Asian population. However, no study reported significant association. We consider that the failure to replicate significant association between rs744373 polymorphism and AD may be caused by the relatively small sample size. In this research, we evaluated this association using pooled samples from previous studies (n = 4982, 1437 AD cases and 3545 controls). Two methods including pooled analysis and meta-analysis were used to investigate the association. Using the pooled analysis, we observed significant association between rs744373 polymorphism and AD by both genotype test (P = 3.94E−03, 4.59E−03 and 1.04E−02) and allele test (P = 1.12E−03, OR = 1.16, 95% CI 1.06-1.28). Interestingly, the meta-analysis confirmed this association with P = 8.00E−03 (OR = 1.14, 95% CI 1.03-1.25) and P = 2.00E−02 (OR = 1.16, 95% CI 1.02-1.32). We also evaluated the effect of rs744373 polymorphism on AD risk in different ethnic backgrounds and found that rs744373 polymorphism contributed to AD with similar genetic risk in East Asian and Caucasian populations. To our knowledge, this is the first study to show significant association between rs744373 polymorphism and AD in East Asian population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 544, 7 June 2013, Pages 47-51
نویسندگان
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