In vitro antimalarial activity of ICL670: A further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin

► ICL670 in vitro antimalarial activity is supported by the inhibition of β-hematin formation. ► ICL670 also inhibits the peroxidative degradation of hemin. ► Ursolic acid derivatives share common structural determinants with ICL670. ► The antimalarial activity and common structural determinants are correlated.