Evaluation of the role of angiogenic factors in the pathogenesis of schistosomiasis

► Vascular endothelial growth factor is detected in patients diagnosed of schistosomiasis. ► Reduction of worms, eggs recovery and granuloma formation is observed in mice treated with endostatin (angiogenesis inhibitor). ► Specific antigen of Schistosoma mansoni from cercariae stimulated VEGF and FGF2 production by alveolar macrophages.