کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6313876 | 1619054 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prenatal exposure to PCB-153, p,pâ²-DDE and birth outcomes in 9000 mother-child pairs: Exposure-response relationship and effect modifiers
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کلمات کلیدی
General Additive ModelsDichlorodiphenyldichloroethylene (DDE)PCB-153GAMdichlorodiphenyldichloroethyleneINMAGRdGWGHCBdichlorodiphenyltrichloroethaneo,p′-DDT - o، p'-DDTp,p′-DDE - p، p'-DDEPersistent organic pollutants - آلایندههای آلی دیرپا(پایدار)p-value - ارزش pGestational weight gain - افزایش وزن حاملگیstandard deviation - انحراف معیارHexachlorobenzene - بنزن هگزاکلراید، هگزاکلروبنزنbiomarkers of exposure - بیومارکرها قرار گرفتن در معرضPercentile - درصدPolychlorinated biphenyls (PCBs) - دیفنیلهای پلی کلر (PCBs)rhea - ریاDAGs - زمانCord serum - سرم بند نافMaternal serum - سرم مادرانbody mass index - شاخص توده بدنBMI - شاخص توده بدنیBreast milk - شیر مادرp,p′-DDT - ص، p'-DDTconfidence interval(s) - فاصله اطمینان)odds ratio - نسبت شانس هاdirected acyclic graphs - نمودارهای تصادفی هدایت شدهBirth weight - وزن هنگام تولد
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Low-level exposure to polychlorinated biphenyl-153 (PCB-153) and dichlorodiphenyldichloroethylene (p-pâ²-DDE) can impair fetal growth; however, the exposure-response relationship and effect modifiers of such association are not well established. This study is an extension of an earlier European meta-analysis. Our aim was to explore exposure-response relationship between PCB-153 and p-pâ²-DDE and birth outcomes; to evaluate whether any no exposure-effect level and susceptible subgroups exist; and to assess the role of maternal gestational weight gain (GWG). We used a pooled dataset of 9377 mother-child pairs enrolled in 14 study populations from 11 European birth cohorts. General additive models were used to evaluate the shape of the relationships between organochlorine compounds and birth outcomes. We observed an inverse linear exposure-response relationship between prenatal exposure to PCB-153 and birth weight [decline of 194 g (95% CI â 314, â 74) per 1 μg/L increase in PCB-153]. We showed effects on birth weight over the entire exposure range, including at low levels. This reduction seems to be stronger among children of mothers who were non-Caucasian or had smoked during pregnancy. The most susceptible subgroup was girls whose mothers smoked during pregnancy. After adjusting for absolute GWG or estimated fat mass, a reduction in birth weight was still observed. This study suggests that the association between low-level exposure to PCB-153 and birth weight exists and follows an inverse linear exposure-response relationship with effects even at low levels, and that maternal smoking and ethnicity modify this association.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environment International - Volume 74, January 2015, Pages 23-31
Journal: Environment International - Volume 74, January 2015, Pages 23-31
نویسندگان
Maribel Casas, Mark Nieuwenhuijsen, David MartÃnez, Ferran Ballester, Xavier Basagaña, Mikel Basterrechea, Leda Chatzi, Cécile Chevrier, Merete Eggesbø, Mariana F. Fernandez, Eva Govarts, Mònica Guxens, Joan O. Grimalt, Irva Hertz-Picciotto,