کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6399661 | 1330704 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rambutan rind in the management of hyperglycemia
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Plant extracts have been suggested as a rich as yet unexplored source of potentially useful anti-diabetic drugs. Recent scientific investigations have confirmed the efficacy of many of these preparations, as effective antioxidants; able to regenerate functional pancreatic beta cells and has a hypoglycemic potential. In this study, the exotic rambutan (Nephelium lappaceum L.) fruit's rind has been shown to be effective in inhibiting the carbohydrate hydrolyzing enzymes, alpha glucosidase (EC50 = 2.7 μg/mL) and alpha amylase (EC50 = 70.8 μg/mL), at a much more significant level than the drug acarbose (EC50 = 3500 μg/mL; alpha glucosidase; EC50 = 12 μg/mL; alpha amylase). In addition, the geraniin-enriched ethanolic extracts were able to inhibit the key enzyme in the polyol pathway, aldol reductase (EC50 = 0.04 μg/mL) and prevent the formation of advanced glycation end-products (AGE) by 43%. These findings indicate that the geraniin-standardized N. lappaceum rind may be a potential source of an anti-hyperglycemic agent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Research International - Volume 44, Issue 7, August 2011, Pages 2278-2282
Journal: Food Research International - Volume 44, Issue 7, August 2011, Pages 2278-2282
نویسندگان
Uma Palanisamy, Thamilvaani Manaharan, Ling Lai Teng, Ammu K.C. Radhakrishnan, Thavamanithevi Subramaniam, Theanmalar Masilamani,