کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6481650 | 1400352 | 2016 | 9 صفحه PDF | دانلود رایگان |
- IAV infection activates transcription of antiviral genes.
- NS1 protein of IAV binds cellular DNA.
- NS1-dsDNA interaction prevents loading of transcriptional machinery.
- Thus, NS1 suppresses IAV-mediated transcription of antiviral genes.
Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication.
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1859, Issue 11, November 2016, Pages 1440-1448