کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6804881 | 1433559 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Declines in inflammation predict greater white matter microstructure in older adults
ترجمه فارسی عنوان
کاهش در التهاب، میکروارگانیسم ماده سفید بیشتری را در افراد مسن پیش بینی می کند
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Protracted systemic inflammation has been associated with adverse effects on cognition and brain structure and may accelerate neurodegenerative disease processes; however, it is less clear whether changes in inflammation are associated with brain structure. We studied 276 black and white older adults (mean age = 83 years at time of imaging) enrolled in a prospective study of aging. Inflammation (measured with c-reactive protein, CRP) was assessed repeatedly over 6 years (i.e., year 2, 4, 6, and 8). Brain magnetic resonance imaging (MRIs) were obtained at years 10-11 with diffusion tensor imaging; regions of interest included late-myelinating areas vulnerable to aging, including frontal-parietal (superior longitudinal fasciculus [SLF]-dorsal) and temporal (SLF-temporal; uncinate) white matter tracts. Mean CRP values significantly declined (t = â5.54, p < 0.0001) over 6 years, and subject-specific slopes (best linear unbiased predictors of slopes) all showed a decline (mean = â0.57, standard deviation = 0.53) for our participant sample. More than 50% of study participants were still in the moderate to high cardiovascular risk range based on CRP values at year 8. After controlling for demographics, vascular risk factors and MRI white matter hyperintensities, larger decreases in CRP values over time were significantly associated with higher fractional anisotropy in the SLF-dorsal (beta = â0.0052, standard error [SE] = 0.003; 95% confidence interval [CI] = â0.0103 to â0.0025, p = 0.04), SLF-temporal (beta = â0.0109, SE = 0.004; 95% CI = â0.0189 to â0.0029, p = 0.008), and uncinate (beta = â0.0067, SE = 0.003; 95% CI = â0.0132 to â0.0001, p = 0.05) fasciculi. Results suggest that in a prospective cohort of older individuals, faster declines in inflammation over time are related to indicators of white matter health, even after accounting for vascular risk factors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 2, February 2015, Pages 948-954
Journal: Neurobiology of Aging - Volume 36, Issue 2, February 2015, Pages 948-954
نویسندگان
Brianne Magouirk Bettcher, Kristine Yaffe, Robert M. Boudreau, John Neuhaus, Howard Aizenstein, Jingzhong Ding, Stephen B. Kritchevsky, Lenore J. Launer, Yongmei Liu, Suzanne Satterfield, Caterina Rosano, Health ABC study Health ABC study,