کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6808455 | 1433592 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Accumulation of murine subretinal macrophages: effects of age, pigmentation and CX3CR1
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Macrophages or activated microglia in the subretinal space are considered a hallmark of some retinal pathologies. We investigated the effects of age, pigmentation and CX3CR1 deficiency on the accumulation of macrophages/activated microglia in the outer retina of young and old Cx3cr1gfp/gfp (CX3CR1-deficient) or Cx3cr1gfp/+ mice on either a pigmented (C57BL/6) or albino (BALB/c) background. Quantitative analysis of immunostained retinal-choroidal whole mounts revealed an increase in subretinal macrophage (SRMΦ) numbers in young Cx3cr1gfp/gfp mice compared with Cx3cr1gfp/+ mice, however the increase was more marked in albino Cx3cr1gfp/gfp mice. In aged mice, large numbers of SRMΦ/activated microglia replete with autofluorescent debris were noted in both old pigmented Cx3cr1gfp/gfp and Cx3cr1gfp/+ mice proving this accumulation was not CX3CR1-dependent. While CX3CR1 deficiency leads to an early onset of SRMΦ accumulation, our data reveal that this change occurs in both aged Cx3cr1gfp/+ and Cx3cr1gfp/gfp pigmented mice in the absence of marked retinal degeneration and is likely a normal response to aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 33, Issue 8, August 2012, Pages 1769-1776
Journal: Neurobiology of Aging - Volume 33, Issue 8, August 2012, Pages 1769-1776
نویسندگان
Holly R. Chinnery, Samuel McLenachan, Timothy Humphries, Jelena M. Kezic, Xiangting Chen, Marc J. Ruitenberg, Paul G. McMenamin,