کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6815275 | 545691 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genome-wide linkage scan of quantitative traits representing symptom dimensions in multiplex schizophrenia families
ترجمه فارسی عنوان
پیوند ژنومیک اسکن از صفات کمی نشان دهنده ابعاد علامت در خانواده های چندگانه اسکیزوفرنیا است
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کلمات کلیدی
جنون جوانی، ابعاد نشانه، تجزیه و تحلیل فاکتور، صفات کمی، تجزیه و تحلیل اتصال،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Symptom dimensions of schizophrenia are likely to be the intermediate phenotypes under the control of disease-susceptibility genes, or separate traits related to disease-modifier genes. This study aimed to identify chromosomal loci linked to symptom dimensions of schizophrenia through genome-wide quantitative trait locus (QTL) linkage analysis. The study subjects consisted of 56 families with 183 members including 123 affected individuals. Symptom evaluations were performed on lifetime basis. Through principal component factor analysis, eight quantitative phenotypes representing symptom dimensions were identified. Genotyping was done for 6008 SNP markers, and genome-wide QTL linkage analysis was performed. No symptom dimension showed a significant linkage attaining genome-wide empirical thresholds. We observed seven regions yielding linkage signals attaining genome-wide empirical thresholds for suggestive linkage (NPL Z score=2.78-3.49); chromosome 15q26.1 for 'non-paranoid delusion factor', 2p24.3 and 7q31.1 for 'prodromal impairment factor', 1q32.1, 9p21.3, and 9q31.2 for 'negative symptom factor', and 10p13 for 'disorganization factor'. Among these loci, chromosome 2p24.3 and 1q32.1 overlap with susceptibility loci of schizophrenia identified in our previous linkage studies. This study suggests the existence of genetic loci related to various clinical features of schizophrenia. Further genetic analyses for these dimensional phenotypes are warranted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 210, Issue 3, 30 December 2013, Pages 756-760
Journal: Psychiatry Research - Volume 210, Issue 3, 30 December 2013, Pages 756-760
نویسندگان
Seunghyong Ryu, Hong-Hee Won, Sohee Oh, Jong-Won Kim, Taesung Park, Eun-Young Cho, Youngah Cho, Dong Yeon Park, Yu-Sang Lee, Jun Soo Kwon, Kyung Sue Hong,