Shared biological pathways for frailty and cognitive impairment: A systematic review

- This systematic review presents the first known findings of the underlying biological characteristics for the relationship between cognitive decline and frailty providing evidence for converging pathophysiological pathways.

- Findings identified a correlation between 13 distinct inflammatory and protein markers with biomarker-related gene expression, identified in both frailty and cognitive decline.
- Findings identified a relationship between shared protein and genetic markers for both cognitive decline and frailty.