کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8257170 1534290 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cellular senescence: Immunosurveillance and future immunotherapy
ترجمه فارسی عنوان
پیری سلولی: ایمنی مراقبت و ایمونوتراپی آینده
کلمات کلیدی
زناشویی، ماکروفاژ، ایمن سازی سالخورده، ایمونوتراپی،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
In response to persistent DNA damage, induction into cell senescence promotes an immunogenic program which facilitates immune clearance of these damaged cells. Under physiological conditions, senescent cells can activate both innate and adaptive immune responses, functioning to maintain tissue homeostasis. In addition, emerging findings suggest that programmed induction of cell senescence may be important for regulating reproductive processes, partly facilitated by immune clearance. However, likely owing to ageing of the immune system, a failure to eliminate senescent cells can contribute to their persistence in tissues, leading to the development and progression of age-related diseases. Such immune failure may in part be due to activation of the senescence program in immune cells, leading to their dysfunction. Furthermore, senescent cells under certain biological contexts have been shown to instead promote immune suppression, a response that may reflect differences between an acute verses chronic senescent phenotype. In this review, we provide an overview of the research to date concerning senescence immunosurviellance, including a focused discussion on the mechanisms by which macrophages may recognise senescent cells. Senescence immunotherapy strategies as an alternative to senolytics for the removal of senescent cells will also be discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 43, May 2018, Pages 17-25
نویسندگان
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