Prevention and reversal of hepatic steatosis with a high-protein diet in mice

► High-protein (HP) diets decrease steatosis with or without pre-existing fatty liver. ► HP diets reverse steatosis more efficiently than a 20% reduced energy intake. ► The anti-steatotic effect of HP diets is independent of fat and carbohydrate intake. ► HP diets induce small, synergistic increases in lipid and amino-acid catabolism. ► HP diets decrease cell stress.