Biliverdin reductase-A protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment

► Increased biliverdin reductase (BVR) expression in AD and MCI hippocampus. ► Decreased phosphorylations (pSer/Thr and pTyr) on BVR in AD and MCI hippocampus. ► Decrease in BVR phosphorylation was associated with reduced activity. ► No change were observed in cerebellum, which lacks pathology in AD and MCI.