کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8263896 | 1534881 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Methyl 3,4-dihydroxybenzoate extends the lifespan of Caenorhabditis elegans, partly via W06A7.4 gene
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کلمات کلیدی
C. elegansH2DCF-DADMSO - DMSORNA interference - RNA تداخل کنندهROS - ROSAmpicillin - آمپی سیلینisopropyl β-D-thiogalactopyranoside - ایزوپروپیل β-D-thiogalactopyranosideTetracycline - تتراسایکلینDimethylsulfoxid - دی متیل سولفوکسیدResveratrol - رسوراترولAging - سالخوردگیLifespan - طول عمرCaenorhabditis elegans - کرم الگانس Reactive oxygen species - گونههای فعال اکسیژنJuglone - یوگلون
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To identify and analyze the compounds that delay aging and extend the lifespan is an important aspect of the gerontology research. A number of compounds, including the ones with the antioxidant properties, have been shown to extend the lifespan of Caenorhabditis elegans. Here, we report that methyl 3,4-dihydroxybenzoate (MDHB), a small antioxidant molecule, prolongs the C. elegans' lifespan under normal as well as stress conditions, delays the age-associated decline in the pharyngeal pumping rate, and obviously enhances the abilities of scavenging intracellular reactive oxygen species (ROS). To further investigate the mechanism underlying the anti-aging action of MDHB, microarray analyses were performed, which demonstrated that 13 genes were differentially expressed in worms treated with MDHB for 48 and 144Â h in common. RNA interference of W06A7.4 (NM_001269697.1), the most significantly up-regulated gene, shortened the lifespan of worms by 14%, compared with the L4440 control. Our findings demonstrate that W06A7.4 is a potentially positive determinant of the MDHB induced C. elegans' lifespan extension effect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 60, December 2014, Pages 108-116
Journal: Experimental Gerontology - Volume 60, December 2014, Pages 108-116
نویسندگان
Wei Zhang, Liang Cai, Hai-Ju Geng, Chao-Fen Su, Li Yan, Jia-Hui Wang, Qin Gao, Huan-Min Luo,