کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8276541 | 1535115 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evidence for peripheral immune activation in amyotrophic lateral sclerosis
ترجمه فارسی عنوان
شواهد برای فعال سازی ایمنی محیطی در اسکلروز جانبی آمیوتروفی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
There is evidence of the activity of immune system in the spinal cords of patients with amyotrophic lateral sclerosis (ALS), however; few studies to date have explored the status of peripheral immune response in ALS patients. Blood samples from 284 ALS patients and 217 aged-match controls were evaluated, and parameters of T cell subset, humoral immunity, and complement system activation were observed. CD4Â + T lymphocytes and circulating immune complexes (CICs) were significantly decreased, and component C3 was significantly increased in ALS patients compared with normal controls. Patients with severe or moderate impairment had a higher CD4Â + T cell percentage and a lower IgG levels when compared to those with mild impairment. There was an inverse correlation between CD4 T cell percentage and both revised ALS Functional Rating Scale (ALSFRS-R) score and disease duration, but the correlation was positive between IgG level and both ALSFRS-R score and disease duration among ALS patients. These correlations were gender-specific. This investigation demonstrated the existence of peripheral immune abnormalities in ALS patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 347, Issues 1â2, 15 December 2014, Pages 90-95
Journal: Journal of the Neurological Sciences - Volume 347, Issues 1â2, 15 December 2014, Pages 90-95
نویسندگان
Xueping Chen, Weihua Feng, Rui Huang, Xiaoyan Guo, Yongping Chen, Zhenzhen Zheng, Huifang Shang,