Low resolution structural characterization of the Hsp70-interacting protein - Hip - from Leishmania braziliensis emphasizes its high asymmetry

► We obtained and studied the Hsp70-interacting protein of Leishmania braziliensis (LbHip). ► The LbHip is a dimer presenting high asymmetry. ► Chemical-induced unfolding data suggested that LbHip is a modular protein.. ► We developed low resolution models for LbHip. ► Our data suggest that LbHip is similar to mammalian Hip, despite the low identity.