کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8320323 | 1539360 | 2018 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Autologous reference types can confound the detection of somatic mutation in solid cancers
ترجمه فارسی عنوان
انواع مرجع اتولوگ ممکن است در تشخیص جهش های سوپنتی در سرطان های محکم قرار گیرند
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کلمات کلیدی
THCATCGABRCATNMhNSCGLMMPRADWGSCHOLSTADACCICGCEsca - ESCAstomach adenocarcinoma - آدنوکارسینوم معدهPancreatic adenocarcinoma - آدنوکارسینوم پانکراسProstate adenocarcinoma - آدنوکارسینوم پروستاتThe cancer genome atlas - اوتومتر ژنوم سرطانWhole genome sequencing - توالی یابی کامل ژنومSomatic mutation - جهش سومیCancer - سرطانOvarian cancer - سرطان تخمدانlung adenocarcinoma - سرطان ریهEsophageal cancer - سرطان مریbladder urothelial carcinoma - سرطان پروستات مثانهBreast cancer - سرطان پستانLiver cancer - سرطان کبدLUAD - لویدGeneralized linear mixed model - مدل ترکیبی خطی متداولLICA - چهرهThyroid carcinoma - کارسینوم تیروئیدLung squamous cell carcinoma - کارسینوم سلول سنگفرشی ریهHead and neck squamous cell carcinoma - کارسینوم سلول سنگفرشی سر و گردنAdrenocortical carcinoma - کارسینوم عروق کرونرCholangiocarcinoma - کلانژیوکارسینومایInternational Cancer Genome Consortium - کنسرسیوم ژنوم بین المللی سرطانCoca - کوکاLUSC - یک چشم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Vast number of somatic mutations has been proved to be affected by the factors of sequencing methods, analysis pipelines and validation methods. We here showed the effect of autologous reference types on the detection of cancer-associated somatic mutations with the somatic single nucleotide variations (SNVs) and clinical data of solid tumors from the Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC). The distribution of somatic SNVs was significantly different among groups of autologous references in 6 cancers detected by whole genome sequencing (WGS) and 5 cancers detected by the random sequencing of exonic regions selected from the genome (WXS), especially in protein coding region of 5 cancers with age, gender and TNM adjusted. In addition, only 60.24% (95% CI: 49.65%-70.83%) of the somatic SNVs called from normal blood by WXS were found in those called from normal solid tissue tested by WXS / WGS, while 31.78% (95%CI: 4.14%-59.42%) of the somatic SNVs called from normal tissue adjacent to primary by WXS were found in those from normal blood tested by WXS / WGS. These findings suggested that more representative types of normal tissues should be included in detection of cancer-associated somatic mutations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 69, September 2018, Pages 6-13
Journal: DNA Repair - Volume 69, September 2018, Pages 6-13
نویسندگان
Xiaoliang Chen, Xiaochun Zou, Weiyi Zhong, Ke Peng, Dongli Wang, Wei Fan, Jinbo Lin, Ji Peng,