Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1

- E. coli cytotoxic necrotizing factor 1 induces expression of the cell death-regulating GTPase RhoB.
- RhoB expression is based on transcriptional activation and involves Rac1-c-Myc signaling.
- RhoB suppresses cell cycle progression and cell death in CNF1-treated cells.