کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336455 | 1540617 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dietary red raspberries attenuate dextran sulfate sodium-induced acute colitis
ترجمه فارسی عنوان
تمشک قرمز رژیم غذایی کاهش کولیت حاد ناشی از سدیم کورتیزون سولفات را کاهش می دهد
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کلمات کلیدی
COX-2ZO-1DAIIBDAMPKDSSNF-κBXanthine oxidase - زانتین اکسیدازAMP-activated protein kinase - AMP-پروتئین کیناز فعال شده استROS - ROStight junctions - اتصالات محکمColitis - التهاب روده بزرگinflammation - التهاب( توروم) interleukin - اینترلوکینInflammatory bowel disease - بیماریهای التهابی رودهRed raspberry - تمشک قرمزDextran sulfate sodium - سولفات سدیم دکسترانdisease activity index - شاخص فعالیت بیماریUlcerative colitis - کولیت اولسراتیوReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Persistent intestinal inflammation severely impairs intestinal integrity resulting in inflammatory bowel disease. Red raspberries (RB) are a rich source of bioactive compounds; their beneficial effect on the colitis protection was evaluated in the current study using a dextran sulfate sodium (DSS)-induced acute colitis mouse model. Six-week-old mice were fed a standard rodent research diet supplemented with RB (0 or 5% w/w, n=20 each group) for 6 weeks. At the 4th week of dietary treatment, approximately half of mice in each dietary group (n=12 each group) were subjected to 2.5% DSS induction for 6 days, followed by 6 days of recovery, to induce colitis. RB supplementation decreased body weight loss (Pâ¤.01), disease activity index (Pâ¤.01), and colon shortening (Pâ¤.05) in DSS-treated mice. In addition, RB supplementation protected the colonic structure (Pâ¤.01), associated with suppressed NF-κB signaling and reduced expression of inflammatory interleukin (IL)-1β, IL-6, IL-17, cyclooxegenase-2, and tumor necrosis factor-α in DSS-treated mice. RB supplementation reduced neutrophil infiltration, monocyte chemoattractant protein-1 mRNA expression, and xanthine oxidase content, but enhanced catalase content in DSS-treated mice. Consistently, RB supplementation reduced pore forming tight junction protein claudin-2, increased barrier strengthening claudin-3, zonula occluden-1 protein content and mucin (MUC)-2 mRNA level, and activated AMP-activated protein kinase (AMPK) in DSS-treated mice. In conclusion, dietary RB protected against inflammation and colitis symptoms induced by DSS, providing a promising dietary approach for the management of colitis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 51, January 2018, Pages 40-46
Journal: The Journal of Nutritional Biochemistry - Volume 51, January 2018, Pages 40-46
نویسندگان
Shima Bibi, Yifei Kang, Min Du, Mei-Jun Zhu,