کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8337506 | 1540677 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Glucose acts as a regulator of serum iron by increasing serum hepcidin concentrations
ترجمه فارسی عنوان
گلوکز با افزایش غلظت هپسیدین سرم به عنوان یک تنظیم کننده آهن سرم عمل می کند
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کلمات کلیدی
هپسیدین، گلوکز، ²-سلول، آهن سرم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Mutual clinical and molecular interactions between iron and glucose metabolism have been reported. We aimed to investigate a potential effect of glucose on iron homeostasis. We found that serum iron concentrations gradually decreased over 180 min after the administration of 75 g of glucose from 109.8±45.4 mg/L to 94.4±40.4 mg/L (P<.001; N= 40) but remained unchanged in control subjects receiving tap water (N= 21). Serum hepcidin, the key iron regulatory hormone which is mainly derived from hepatocytes but also expressed in pancreatic β-cells, increased within 120 min after glucose ingestion from 19.7±9.9 nmol/L to 31.4±21.0 nmol/L (P<.001). In cell culture, glucose induced the secretion of hepcidin and insulin into the supernatant of INS-1E cultures, but did not change the amount of hepcidin detectable in the hepatocyte cell culture HepG2. We additionally confirmed the expression of hepcidin in a human islet cell preparation. These results suggest that glucose acts as a regulator of serum iron concentrations, most likely by triggering the release of hepcidin from β-cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 24, Issue 1, January 2013, Pages 112-117
Journal: The Journal of Nutritional Biochemistry - Volume 24, Issue 1, January 2013, Pages 112-117
نویسندگان
Elmar Aigner, Thomas K. Felder, Hannes Oberkofler, Penelope Hahne, Simon Auer, Selma Soyal, Andreas Stadlmayr, Karin Schwenoha, Christian Pirich, Paul Hengster, Christian Datz, Wolfgang Patsch,