کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8339993 1541186 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An integrative approach to investigate the association among high-sensitive C-reactive protein, body fat mass distribution, and other cardiometabolic risk factors in young healthy women
ترجمه فارسی عنوان
یک رویکرد یکپارچه برای بررسی ارتباط بین پروتئین واکنش پذیر با حساسیت بالا، توزیع توده چربی بدن و سایر عوامل خطر ابتلا به قلب و عروق در زنان سالم جوان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Prior research has indicated that as an important biomarker of chronic low-grade inflammation, high-sensitivity C-reactive protein (hs-CRP) can play important roles on the onset of metabolic syndrome and cardiovascular diseases (CVD). We conducted an integrative approach, which combines biological wet-lab experiments, statistical analysis, and semantics-oriented bioinformatics & computational analysis, to investigate the association among hs-CRP, body fat mass (FM) distribution, and other cardiometabolic risk factors in young healthy women. Research outcomes in this study resulted in two novel discoveries. Discovery 1: There are four primary determinants for hs-CRP, i.e., central/abdominal FM (a.k.a. trunk FM) accumulation, leptin, high density lipoprotein cholesterol (HDL-C), and plasminogen activator inhibitior-1 (PAI-1). Discovery 2: Chronic inflammation may involve in adipocyte-cytokine interaction underlying the metabolic derangement in healthy young women.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Methods - Volume 145, 1 August 2018, Pages 60-66
نویسندگان
, , , , , , , ,