کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8347968 | 1541708 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes
ترجمه فارسی عنوان
پپتید اسپگزین در بافت های اندوکرین و بافت اپیتلیال بیان می شود و پس از گلوکز در دیابت نوع 2 کاهش می یابد
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کلمات کلیدی
اسپکسین، بافت غدد درون ریز، بافت مخاطی، انسان، دیابت نوع 2،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Spexin mRNA and protein are widely expressed in rat tissues and associate with weight loss in rodents of diet-induced obesity. Its location in endocrine and epithelial cells has also been suggested. Spexin is a novel peptide that involves weight loss in rodents of diet-induced obesity. Therefore, we aimed to examine its expression in human tissues and test whether spexin could have a role in glucose and lipid metabolism in type 2 diabetes mellitus (T2DM). The expression of the spexin gene and immunoreactivity in the adrenal gland, skin, stomach, small intestine, liver, thyroid, pancreatic islets, visceral fat, lung, colon, and kidney was higher than that in the muscle and connective tissue. Immunoreactive serum spexin levels were reduced in T2DM patients and correlated with fasting blood glucose (FBG, r = â0.686, P < 0.001), hemoglobin A1c (HbA1c, r = â0.632, P < 0.001), triglyceride (TG, r = â0.236, P < 0.001) and low density lipoprotein-cholesterol (LDL-C, r = â0.382, P < 0.001). A negative correlation of blood glucose with spexin was observed during oral glucose tolerance test (OGTT). Spexin is intensely expressed in normal human endocrine and epithelial tissues, indicating that spexin may be involved in physiological functions of endocrine and in several other tissues. Circulating spexin levels are low in T2DM patients and negatively related to blood glucose and lipids suggesting that the peptide may play a role in glucose and lipid metabolism in T2DM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 71, September 2015, Pages 232-239
Journal: Peptides - Volume 71, September 2015, Pages 232-239
نویسندگان
Liping Gu, Yuhang Ma, Mingyu Gu, Ying Zhang, Shuai Yan, Na Li, Yufan Wang, Xiaoying Ding, Jiajing Yin, Nengguang Fan, Yongde Peng,