کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8350240 | 1541836 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Muscarinic, nicotinic and GABAergic receptor signaling differentially mediate fat-conditioned flavor preferences in rats
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Rats display conditioned flavor preferences (CFP) for fats. Previous studies demonstrated that whereas expression of an already-acquired corn oil (CO)-CFP was mildly reduced by dopamine (DA) D1, DA D2, NMDA or opioid receptor antagonists, the acquisition or learning of CO-CFP was eliminated by NMDA antagonists, and significantly reduced by DA D1 and D2, but not opioid antagonists. Previous studies of fructose-CFP demonstrated that muscarinic (scopolamine) and nicotinic (mecamylamine) cholinergic receptor antagonists and GABAB (baclofen) receptor agonism reduced the expression of this acquired response, and that scopolamine, but not mecamylamine or baclofen eliminated the acquisition or learning of this response. The present study examined scopolamine, mecamylamine or baclofen effects upon expression or acquisition of CO-CFP. For expression, rats were trained over 10 sessions with CSÂ + (3.5% CO) and CSÂ â (0.9% CO) flavored solutions without drugs. Two-bottle choice tests with CSÂ + and CSÂ â flavors in 0.9% CO examined preferences following vehicle, scopolamine (1-10Â mg/kg), mecamylamine (1-8Â mg/kg) and baclofen (1.5-5Â mg/kg). In acquisition, eight groups of rats received vehicle, scopolamine (1, 2.5Â mg/kg), mecamylamine (4, 6Â mg/kg), baclofen (3, 5Â mg/kg) or a limited intake vehicle control 0.5Â h prior to all 10 CSÂ + and CSÂ â training sessions followed by six 2-bottle CSÂ + and CSÂ â choice tests in 0.9% CO. CO-CFP expression (percent CSÂ + intake) was significantly but marginally reduced by scopolamine (70%), mecamylamine (85%) and baclofen (74%) relative to vehicle (98%). CO-CFP acquisition was eliminated (41%) by scopolamine relative to vehicle (88%) and limited control (98%) conditions. Neither mecamylamine nor baclofen altered CO-CFP acquisition. Thus, the muscarinic cholinergic receptor system is essential for acquisition (learning) of both fat-induced and sugar (fructose)-induced preferences. In contrast, muscarinic, nicotinic and GABAB receptors were minimally involved in the expression (maintenance) of fat- and fructose-CFP.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volumes 150â151, NovemberâDecember 2016, Pages 14-21
Journal: Pharmacology Biochemistry and Behavior - Volumes 150â151, NovemberâDecember 2016, Pages 14-21
نویسندگان
Francis M. Rotella, Kerstin Olsson, Nancy Martinez, Alexandra Mordo, Ilanna Kohen, Alon Aminov, Jeremy Pagirsky, Alice Yu, Vishal Vig, Richard J. Bodnar,